The Dukes of Hazzard (1979)

S7E3 Dr. Jekyll and Mr. Duke

After Luke accidentally consumes pond water contaminated by a truckload of genetic drugs, his personality takes a drastic turn. He transforms into a complete bully, insulting Bo, Daisy, and Jesse, and relentlessly pestering every girl at the Boar's Nest. As his behavior spirals further out of control, Luke hatches a plan to rob Boss' bank, showcasing a side of him that his friends barely recognize.