The Venture Bros. (2004)

S3E2 The Doctor Is Sin

Dr. Venture discovers that a life devoid of a true nemesis lacks excitement when he is inundated by a swarm of second-rate villains vying for the Monarch's crown. As he grapples with these wannabe adversaries, his super-science enterprise faces yet another crisis, leaving him to reconsider the value of his long-time rivalry.