The Thick of It (2005)

S2E11 Owner of a Lonely Heart

Cristina Yang shows no compassion for Constance Ferguson, a prisoner portrayed by special guest star Rosanna Arquette, who risks her well-being to escape solitary confinement. Meanwhile, the interns closely monitor the family of premature quintuplets facing multiple severe health issues. Tensions rise as Izzie's frustration with Alex escalates, while Dr. Addison Shepherd opts to impart a harsh lesson to Izzie, making her experience a difficult one.